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Many users combat the estrogenic side effects with anastrozole, tamoxifen or clomifene.In addition, as with other 17α-alkylated steroids, the use of metandienone over extended periods of time can result in liver damage without appropriate precautions.

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Generic production shut down two years later, when the FDA revoked metandienone's approval entirely in 1985.

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Beginning soon afterwards in 1959, CIBA collaborated with John Bosley Ziegler (a physician specializing in physical rehabilitation and an early pioneer of pharmaceutical performance enhancement) to test the effects of Dianabol on professional weightlifters.

Ziegler had a close relationship with Bob Hoffman, owner of York Barbell Company and coach of the US Olympic weightlifting team, The first tentative experiments were disappointing. America winner Jim Park reported that "its only effect was to give him an instant erection upon seeing any female." However, Ziegler believed that Dianabol had significant potential as an anabolic.Among the first subjects were John Grimek, Bill March, Charles Vinci, and Louis Riecke, as well as Ziegler and Hoffman themselves.

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